Acetaminophen poisoning refers to the ingestion of a toxic dose of the medication acetaminophen, also known as paracetamol. Acetaminophen is commonly used as a pain reliever and fever reducer, but overdose can lead to severe liver damage and even death if not treated promptly. Research in this area focuses on understanding the mechanisms of acetaminophen toxicity, identifying risk factors for overdose, developing better diagnostic tests, and improving treatment strategies. This includes studying the metabolism of acetaminophen in the liver, investigating the role of oxidative stress and inflammation in liver damage, and exploring potential antidotes or therapies to prevent or reverse toxicity. Overall, research on acetaminophen poisoning aims to improve prevention, diagnosis, and management of overdose cases to reduce the high morbidity and mortality associated with this common medication poisoning.